Open AccessComprehensive molecular profiling of extrahepatic cholangiocarcinoma in Chinese population and potential targets for clinical practice
Author(s) -
Xue Li,
Chao Guo,
Kang Zhang,
Hang Jiang,
Fei Pang,
Ying Dou,
Xiaoyan Liu,
Hanqing Lin,
Xiaowei Dong,
Shuaiguo Zhao,
Ming Yao,
Kai Wang,
Yujie Feng,
Weiguang Gu
Publication year - 2019
Publication title -
hepatobiliary surgery and nutrition
Language(s) - English
Resource type - Journals
eISSN - 2304-389X
pISSN - 2304-3881
DOI - 10.21037/hbsn.2019.08.05
Subject(s) - cdkn2a , kras , medicine , arid1a , cohort , oncology , population , targeted therapy , cancer research , mapk/erk pathway , chinese population , bioinformatics , gene , mutation , genotype , cancer , genetics , biology , kinase , colorectal cancer , environmental health
Cholangiocarcinoma (CCA) is a diverse group of malignancies arising from the intra- or extrahepatic biliary epithelium and characterized by its late diagnosis and fatal outcome. Extrahepatic cholangiocarcinoma (ECC) accounts for 90% of CCA. However, little is known about the comprehensive genomic alterations of ECC in Chinese population for providing clinical managements especially targeted therapy.