Open AccessPrevention of neointimal formation after angioplasty using tetramethylpyrazine-coated balloon catheters in a rabbit iliac artery model
Author(s) -
Lijuan Chen,
Suh Chien Pang,
Chunshu Hao,
Aiming Xie,
Kongbo Zhu,
Yanru He,
Xiaoguo Zhang,
Wenbing Lu,
Genshan Ma,
Zhong Chen
Publication year - 2019
Publication title -
cardiovascular diagnosis and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.83
H-Index - 22
eISSN - 2223-3660
pISSN - 2223-3652
DOI - 10.21037/cdt.2019.09.04
Subject(s) - medicine , restenosis , tetramethylpyrazine , neointimal hyperplasia , hyperplasia , neointima , stenosis , proliferating cell nuclear antigen , balloon , urology , artery , immunohistochemistry , surgery , pathology , stent , alternative medicine
Restenosis remains a clinical problem; drug-coated balloons (DCBs) have demonstrated high efficiency in this situation. DCBs prevent neointimal hyperplasia by inhibiting cell proliferation and migration. Tetramethylpyrazine (TMP) is a traditional Chinese medicine originally isolated from the rhizome of Ligusticum Walliichii, which can inhibit platelet aggregation and smooth muscle cell proliferation. We hypothesized that TMP-coated balloons (TCB) could reduce neointimal hyperplasia through the NF-κB signalling pathway.