Prevention of neointimal formation after angioplasty using tetramethylpyrazine-coated balloon catheters in a rabbit iliac artery model | Zendy

Lijuan Chen | Zendy; Si Pang | Zendy; Chunshu Hao | Zendy; Aiming Xie | Zendy; Kongbo Zhu | Zendy; Yanru He | Zendy; Xiaoguo Zhang | Zendy; Wenbing Lu | Zendy; Genshan Ma | Zendy; Zhong Chen | Zendy

Open Access

Prevention of neointimal formation after angioplasty using tetramethylpyrazine-coated balloon catheters in a rabbit iliac artery model

Author(s) -

Lijuan Chen,

Si Pang,

Chunshu Hao,

Aiming Xie,

Kongbo Zhu,

Yanru He,

Xiaoguo Zhang,

Wenbing Lu,

Genshan Ma,

Zhong Chen

Publication year - 2019

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt.2019.09.04

Subject(s) - medicine , restenosis , tetramethylpyrazine , neointimal hyperplasia , hyperplasia , neointima , stenosis , proliferating cell nuclear antigen , balloon , urology , artery , immunohistochemistry , surgery , pathology , stent , alternative medicine

Restenosis remains a clinical problem; drug-coated balloons (DCBs) have demonstrated high efficiency in this situation. DCBs prevent neointimal hyperplasia by inhibiting cell proliferation and migration. Tetramethylpyrazine (TMP) is a traditional Chinese medicine originally isolated from the rhizome of Ligusticum Walliichii, which can inhibit platelet aggregation and smooth muscle cell proliferation. We hypothesized that TMP-coated balloons (TCB) could reduce neointimal hyperplasia through the NF-κB signalling pathway.

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