Open AccessCombination of HGF and IGF-1 promotes connexin 43 expression and improves ventricular arrhythmia after myocardial infarction through activating the MAPK/ERK and MAPK/p38 signaling pathways in a rat model
Author(s) -
Jierong Yao,
Jianting Ke,
Zhengyuan Zhou,
Guangyi Tan,
Yuelan Yin,
Mao Liu,
Jian Chen,
Wei Wu
Publication year - 2019
Publication title -
cardiovascular diagnosis and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.83
H-Index - 22
eISSN - 2223-3660
pISSN - 2223-3652
DOI - 10.21037/cdt.2019.07.12
Subject(s) - hepatocyte growth factor , connexin , mapk/erk pathway , stimulation , medicine , p38 mitogen activated protein kinases , endocrinology , growth factor , in vivo , blot , signal transduction , receptor , gap junction , biology , microbiology and biotechnology , gene , intracellular , biochemistry
In this study, we hypothesized that the combination of hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) alters the expression of connexin 43 (Cx43) and results in a reduced frequency of induced ventricular arrhythmia in rats after myocardial infarction (MI) and explored the preliminary mechanisms involved.