Combination of HGF and IGF-1 promotes connexin 43 expression and improves ventricular arrhythmia after myocardial infarction through activating the MAPK/ERK and MAPK/p38 signaling pathways in a rat model | Zendy

Jierong Yao | Zendy; Jianting Ke | Zendy; Zhijuan Zhou | Zendy; Guangyi Tan | Zendy; Yuelan Yin | Zendy; Mao Liu | Zendy; Jian Chen | Zendy; Wei Wu | Zendy

Open Access

Combination of HGF and IGF-1 promotes connexin 43 expression and improves ventricular arrhythmia after myocardial infarction through activating the MAPK/ERK and MAPK/p38 signaling pathways in a rat model

Author(s) -

Jierong Yao,

Jianting Ke,

Zhijuan Zhou,

Guangyi Tan,

Yuelan Yin,

Mao Liu,

Jian Chen,

Wei Wu

Publication year - 2019

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt.2019.07.12

Subject(s) - hepatocyte growth factor , connexin , mapk/erk pathway , stimulation , medicine , p38 mitogen activated protein kinases , endocrinology , growth factor , in vivo , blot , signal transduction , receptor , gap junction , biology , microbiology and biotechnology , gene , intracellular , biochemistry

In this study, we hypothesized that the combination of hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) alters the expression of connexin 43 (Cx43) and results in a reduced frequency of induced ventricular arrhythmia in rats after myocardial infarction (MI) and explored the preliminary mechanisms involved.

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