Open AccessEmulsified isoflurane protects beta cells against high glucose-induced apoptosis via inhibiting endoplasmic reticulum stress
Author(s) -
Zhenkun Yang,
Shuoxiong Wu,
Jingjing Zhao,
Zuoyu Wang,
Min Yao,
Peihua Lu,
Wenyan Dong,
Jie Sun
Publication year - 2020
Publication title -
annals of palliative medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 19
eISSN - 2224-5839
pISSN - 2224-5820
DOI - 10.21037/apm.2019.11.31
Subject(s) - medicine , xbp1 , endoplasmic reticulum , apoptosis , chop , atf6 , unfolded protein response , blot , microbiology and biotechnology , caspase 12 , endocrinology , programmed cell death , biochemistry , caspase , biology , lymphoma , rna , rna splicing , gene
Pancreatic beta cell damage induced by glucose toxicity is an important factor in type 2 diabetes mellitus (T2DM). It has become evident that endoplasmic reticulum stress (ERS)-induced apoptosis was contributed to beta cell dysfunction and insulin resistance. Our previous work showed that emulsified isoflurane (EIso) could alleviate ERS in lung reperfusion injury. This study aimed to elucidate whether EIso could alleviate apoptosis induced by glucose in rat islet RIN-m5F beta cells via inhibiting ERS.