Open AccessIntra-amygdala infusion of zeta inhibitory peptide attenuates neuropathic pain but not inflammatory pain in adult rats
Author(s) -
Juan Yao,
Ling Zhang,
Weiping Lei,
Yunpeng Huang,
Honghai Zhang,
Bo Lu,
Yong-Xing Yao,
Li Zhao,
Jiao Sun
Publication year - 2019
Publication title -
annals of palliative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 19
eISSN - 2224-5839
pISSN - 2224-5820
DOI - 10.21037/apm.2019.11.21
Subject(s) - medicine , neuropathic pain , inhibitory postsynaptic potential , amygdala , anesthesia , acute pain , pharmacology
Protein kinase Mζ (PKMζ), a typical brain-specic PKC isoform, has been shown to be critical in the maintenance of long-term potentiation and memory storage. Zeta inhibitory peptide (ZIP), a peptide with selective inhibition of PKMζ, has been used in relieving experimental neuropathic pain and disrupting memory. The aim of this study was to investigate the effects of intra-amygdalar infusion of ZIP on neuropathic pain induced by chronic constriction injury (CCI), and inflammatory pain induced by complete Freund's adjuvant (CFA) in adult rats.