Intra-amygdala infusion of zeta inhibitory peptide attenuates neuropathic pain but not inflammatory pain in adult rats | Zendy

Juan Yao | Zendy; Ling Zhang | Zendy; Weiping Lei | Zendy; Yaqin Huang | Zendy; Honghai Zhang | Zendy; Bo Lu | Zendy; Yong-Xing Yao | Zendy; Li Zhao | Zendy; Jianliang Sun | Zendy

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Intra-amygdala infusion of zeta inhibitory peptide attenuates neuropathic pain but not inflammatory pain in adult rats

Author(s) -

Juan Yao,

Ling Zhang,

Weiping Lei,

Yaqin Huang,

Honghai Zhang,

Bo Lu,

Yong-Xing Yao,

Li Zhao,

Jianliang Sun

Publication year - 2019

Publication title -

annals of palliative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 19

eISSN - 2224-5839

pISSN - 2224-5820

DOI - 10.21037/apm.2019.11.21

Subject(s) - medicine , neuropathic pain , inhibitory postsynaptic potential , amygdala , anesthesia , acute pain , pharmacology

Protein kinase Mζ (PKMζ), a typical brain-specic PKC isoform, has been shown to be critical in the maintenance of long-term potentiation and memory storage. Zeta inhibitory peptide (ZIP), a peptide with selective inhibition of PKMζ, has been used in relieving experimental neuropathic pain and disrupting memory. The aim of this study was to investigate the effects of intra-amygdalar infusion of ZIP on neuropathic pain induced by chronic constriction injury (CCI), and inflammatory pain induced by complete Freund's adjuvant (CFA) in adult rats.

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