Open AccessMicroRNA-155 promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the ERK1/2 pathway in THP-1 macrophages and aggravates atherosclerosis in ApoE−/− mice
Author(s) -
Ruihua Yin,
Xiaoyan Zhu,
Jing Wang,
Shaonan Yang,
Aijun Ma,
Qi Xiao,
Jinyang Song,
Xudong Pan
Publication year - 2019
Publication title -
annals of palliative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 19
eISSN - 2224-5839
pISSN - 2224-5820
DOI - 10.21037/apm.2019.10.11
Subject(s) - inflammasome , western blot , inflammation , blot , mapk/erk pathway , microbiology and biotechnology , medicine , microrna , phosphorylation , ldl receptor , apolipoprotein e , cancer research , immunology , chemistry , lipoprotein , biology , pathology , biochemistry , cholesterol , gene , disease
Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation can induce the secretion of IL-1β and IL-18 and after promoting the development of atherosclerosis. MiR-155 is an important microRNA that modulates inflammation in atherosclerosis, but the role of miR-155 in the regulation of the NLRP3 inflammasome is still unknown.