Open AccessExpression of receptor interacting protein 3 and mixed lineage kinase domain-like protein-key proteins in necroptosis is upregulated in ulcerative colitis
Author(s) -
Tielong Wu,
Yuanyuan Dai,
Lili Xue,
Yingyue Sheng,
Linlin Xu,
Yuzheng Xue
Publication year - 2019
Publication title -
annals of palliative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 19
eISSN - 2224-5839
pISSN - 2224-5820
DOI - 10.21037/apm.2019.07.04
Subject(s) - medicine , necroptosis , downregulation and upregulation , lineage (genetic) , ulcerative colitis , cancer research , microbiology and biotechnology , genetics , apoptosis , gene , disease , programmed cell death , biology
Ulcerative colitis (UC) is a chronic inflammatory colonic disease strongly associated with intestinal epithelial cell (IEC) death. Necroptosis is characterized by a newly programmed cell death through a caspase-independent pathway. Receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like protein (MLKL) are very important in the pathway of necroptosis. However, their expression in UC remains unelucidated. This study aimed to investigate the expression of RIP3 and MLKL in patients with UC, along with its correlation with disease activity.