Open AccessASSOCIATION OF MTHFR A1298C POLYMORPHISMWITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS
Author(s) -
Wei Liu,
Yi Li,
Rui Li,
Xiao Han,
Ying Ma,
Bin Liu,
Xiangzhen Kong
Publication year - 2016
Publication title -
african journal of traditional complementary and alternative medicines
Language(s) - English
Resource type - Journals
eISSN - 2505-0044
pISSN - 0189-6016
DOI - 10.21010/ajtcam.v13i5.11
Subject(s) - ovarian cancer , breast cancer , methylenetetrahydrofolate reductase , meta analysis , odds ratio , oncology , medicine , subgroup analysis , genetic model , allele , confidence interval , gynecology , case control study , cancer , biology , genetics , gene
Recent years have witnessed the discovery of similar gene variations between breast cancer and ovarian cancer, inherited breast and ovarian cancer in particular. A large number of case-control studies have been conducted to explore the association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C polymorphism with breast cancer and/or ovarian cancer risk. However, the results are still inconsistent and inconclusive. Consequently, we performed a meta-analysis to evaluate the association between MTHFR A1298C polymorphism and breast, ovarian cancer risk.