Open AccessOmega-3 Polyunsaturated Fatty Acids: the Role in Prevention of Atrial Fibrillation in Patients with Coronary Artery Disease after Coronary Artery Bypass Graft Surgery
Author(s) -
O. A. Rubanenko,
Yu. V. Shchukin,
Л. В. Лимарева,
Т. К. Ryazanova,
А. О. Рубаненко,
И. Л. Давыдкин
Publication year - 2022
Publication title -
racionalʹnaâ farmakoterapiâ v kardiologii
Language(s) - English
Resource type - Journals
eISSN - 2225-3653
pISSN - 1819-6446
DOI - 10.20996/1819-6446-2021-12-02
Subject(s) - medicine , polyunsaturated fatty acid , atrial fibrillation , docosahexaenoic acid , coronary artery disease , malondialdehyde , oxidative stress , artery , cardiology , gastroenterology , cardiac surgery , surgery , anesthesia , fatty acid , biochemistry , chemistry
Aim . To estimate the role of omega-3 polyunsaturated fatty acids (PUFAs) administration in atrial fibrillation (AF) prevention after planned coronary artery bypass graft (CABG) surgery. Material and Methods . Studied were 306 patients divided into two groups: patients of group I didn’t receive PUFAs (158 patients, 82.7% males) and patients of group II received PUFAs (148 patients, 89.3% males). PUFAs were prescribed in daily dose 2000 mg 5 days before surgery and in daily dose 1000 mg in postoperative period during 21 days. Results . Postoperative AF (POAF) occurred in 29.7% patients in group I and in 16.9% patients in group II (р=0.009). We found that after CABG in patients of the I group median IL-6 level was 39.3% higher (p=0.001), interleukin-10 – 20.2% higher (p=0.01), superoxide dismutase – 78.9% higher (р<0.001), malondialdehyde – 33.8% higher (p=0.03), docosahexaenoic acid – 31.8% lower (p=0.01) and omega-3 index – 43.4% lower (p=0.04) than in patients of the II group. According to multivariate regression analysis we found significant association between the factors of inflammation, oxidative stress and the risk POAF development. Conclusions . In patients who took PUFAs, we found less activation of inflammation, oxidative stress, the increasing of docosahexaenoic acid and omega-3 index accompanied by the decreasing of POAF development rates up to 12.8%.