Open AccessRelationship between Chemotherapy and Atrial Fibrillation: Clinical Case
Author(s) -
Ashot Avagimyan,
Lusine Mkrtchyan,
A. A. Gevorkyan,
Н. Б. Конончук,
Lev Kakturskiy,
Z. T. Djndoyan
Publication year - 2021
Publication title -
racionalʹnaâ farmakoterapiâ v kardiologii
Language(s) - English
Resource type - Journals
eISSN - 2225-3653
pISSN - 1819-6446
DOI - 10.20996/1819-6446-2021-10-17
Subject(s) - medicine , cardiotoxicity , anthracycline , atrial fibrillation , chemotherapy , cardiology , adjuvant chemotherapy , heart rhythm , intensive care medicine , cancer , breast cancer
The aim of this article is to represent the characterization of the clinical case of chemotherapy-related atrial fibrillation (AF) development in the young woman, elaborated as a result of multiple neoadjuvant and adjuvant modes of the intake of chemotherapy (both anthracycline based and non-anthracycline ones). In this case, the noted disturbances of heart rhythm should be recognized as a manifestation of cardiotoxicity. The latter implies the degree of detrimental effect of chemotherapeutical medication on the morphophynctional parameters of the cardiovascular system. Anthracycline drugs, being highly effective chemotherapytical agents, provide well-known toxic effects on the heart and vessels. Anthracycline mediated cardiotoxicity is a well- known veracity that dates back to the 60s of the last century, but up to now this medication sustains irreplaceable components of big volume of chemotherapy modes. Moreover, it should be noted that relatively newer drugs also posses certain cardiotoxicogenic potential.