Open AccessPharmacological Basis of the Clinical Efficacy of Varenicline Used to Facilitate Smoking Cessation
Author(s) -
S. R. Gilyarevskiy
Publication year - 2019
Publication title -
racionalʹnaâ farmakoterapiâ v kardiologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.161
H-Index - 9
eISSN - 2225-3653
pISSN - 1819-6446
DOI - 10.20996/1819-6446-2019-15-1-95-104
Subject(s) - varenicline , medicine , smoking cessation , nicotine replacement therapy , addiction , nicotine , concomitant , drug , psychological intervention , pharmacotherapy , intensive care medicine , nicotine addiction , pharmacology , psychiatry , pathology
Modern problems caused by the high prevalence of smoking, as well as pharmacological approaches that facilitate quitting smoking are discussed in the review. Data on the mechanisms of formation of nicotine addiction, which determine the choice of drug interventions aimed at increasing the probability of quitting smoking are presented. The pharmacological characteristics of the most commonly used drugs used to facilitate smoking cessation are given. Special attention is paid to data on the mechanisms of action of varenicline and evidence of its clinical efficacy and safety, including in patients with concomitant cardiovascular diseases, as well as in patients with a history of acute coronary syndrome. Evidence on the effectiveness of the combined use of varenicline and nicotine replacement therapy are presented.