Open AccessInterdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet in obese women
Author(s) -
Carolina Kim Shiba,
Ana Raimunda Dâmaso,
Samantha Ottani Rhein,
Paola Próspero Machado,
Deborah Cristina Landi Masquio,
Lila Missae Oyama,
João Augusto Barreto Lombardi,
Leonardo Lo Duca,
Lian Tock,
Gabriela Iervolino Oliveira,
Raquel Munhoz da Silveira Campos
Publication year - 2020
Publication title -
nutrición hospitalaria
Language(s) - English
Resource type - Journals
eISSN - 1699-5198
pISSN - 0212-1611
DOI - 10.20960/nh.02777
Subject(s) - adiponectin , medicine , adipokine , endocrinology , leptin , obesity , insulin resistance , body mass index , waist , glycemic , cholesterol , weight loss , insulin , abdominal obesity
Background: obesity is a chronic disease associated with inadequate eating habits and reduced levels of physical activity. Because of obesity, the risk for comorbidities is increased, especially for cardiovascular diseases, insulin resistance, and increased pro-inflammatory factors. The aim of the present investigation was to analyze potential correlations between pro/anti-inflammatory adipokines, glycemic index, and other markers of diet quality using a metabolic profile in women undergoing interdisciplinary weight loss therapy. Methods: thirty-two women with obesity were enrolled in a 12-week program of interdisciplinary therapy combining a clinical, nutritional, and physical exercise approach. Body composition, quality of diet, metabolic profile, and pro/anti-inflammatory adipokines were analyzed. Results: the therapy showed to be effective in reducing body weight, body mass index, and body fat. There was also an improvement in lipid profile, including total cholesterol, non-HDL-cholesterol, VLDL-cholesterol, triglycerides and glucose metabolism, including glucose, and insulin. As for food intake, there was a decrease in calorie consumption, carbohydrates, lipids, and glycemic load, and an increased consumption of proteins. Positive correlations were demonstrated between insulin concentration and waist circumference; leptin and body fat and abdominal circumference; and LDL-cholesterol fraction and total cholesterol consumption. Negative correlations were demonstrated between leptin and monosaturated fat consumption; and adiponectin and liver enzyme GGT levels. Conclusions: interdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet. Our findings suggest the effectiveness and clinical relevance of the interdisciplinary clinical therapy applied for obesity.