Open AccessIL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score
Author(s) -
Lidya Turupadang,
Muhammad Fadjar Perkasa,
Abdul Qadar Punagi,
Azmi Mi'rah Zakiah,
Burhanuddin Bahar
Publication year - 2022
Publication title -
n (nusantara) medical science journal
Language(s) - English
Resource type - Journals
eISSN - 2597-7288
pISSN - 2460-9757
DOI - 10.20956/nmsj.v6i2.18765
Subject(s) - nasal polyps , medicine , chronic rhinosinusitis , gastroenterology , correlation , sinusitis , proinflammatory cytokine , immunohistochemistry , surgery , inflammation , mathematics , geometry
IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p<0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p<0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p<0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsNP