Open AccessAnti-adhesive membranes based on crosslinked carboxymethyl cellulose
Author(s) -
V. A. Zhukovskiy,
V. E. Nemilov,
T. S. Filipenko,
T. Y. Anuschenko
Publication year - 2021
Publication title -
vestnik voronežskogo gosudarstvennogo universiteta inženernyh tehnologij
Language(s) - English
Resource type - Journals
eISSN - 2310-1202
pISSN - 2226-910X
DOI - 10.20914/2310-1202-2021-2-191-196
Subject(s) - carboxymethyl cellulose , adhesive , macromolecule , membrane , cellulose , bifunctional , polymer , polymer chemistry , adhesion , copolymer , adipic acid , chemistry , materials science , swelling , chemical engineering , organic chemistry , biochemistry , composite material , sodium , layer (electronics) , engineering , catalysis
In recent times, new anti-adhesion devices including devices based on carboxymethyl cellulose (CMC), which have “barrier” effect are being developed and actively introduced into surgical practice. The “barrier” should be completely resorbed after the time required to healing the morphofunctional integrity of the injured peritoneum, be economically available and easy to use (including laparoscopic technologies). But the time when the CMC is in the body is insufficient to prevent the formation of adhesions, particularly in the presence of non-absorbable rigid implants. The reactive functional groups in CMC allow to transform the CMC-macromolecule into a spatial structure. For this are required the using of bifunctional (bicarboxylic or aminocarboxylic) acids and the transform of a part of the carboxyl groups from the Na-form to the hardly soluble H-form, i.e., it is necessary to crosslink CMC-macromolecules. Adipic acid and glutaric acid, aminoacetic acid and amino capronic acid used are linking agents. The influence of modification parameters on the degree of polymers swelling in water is studied. As a result, to obtain membranes designed for the treatment of adhesive disease, it is recommended to use additives in CMC of bifunctional compounds.