Open AccessPreparation and characterization of baicalein loaded phytosomes: Assessment of in vitro parameters
Author(s) -
KanchanV Zade,
Alok Pal Jain
Publication year - 2020
Publication title -
international journal of pharmtech research
Language(s) - English
Resource type - Journals
eISSN - 2455-9563
pISSN - 0974-4304
DOI - 10.20902/jptr.2019.120404
Subject(s) - baicalein , differential scanning calorimetry , dissolution , chemistry , nuclear chemistry , chromatography , materials science , organic chemistry , pharmacology , medicine , physics , thermodynamics
Phytosome is a complex between natural active ingredient and a phospholipid.Further, phytosomes been applied to many popular herbal extracts or active molecules foraugmenting oral dissolution. Therefore, in present investigation, orally administered Baicalein,atype of flavanoids, is poorly absorbed, and shows suboptimal dissolution. The phytosomesencapsulating baicalein (1:1 Mm) were prepared by reverse phase evaporation method followedby lyophilization. Transmission electron microscopy (TEM) analysis revealed that phytosomeswere almost spherical in shape with particle size below 100 nm. The Powder ex-ray diffraction(PXRD) and differential scanning calorimetry (DSC) demonstrated that Baicalein loadedphytosomes were amorphous in nature. Amorphization of therapeutic moiety leads toimprovement in dissolution. In conclusion, epigallocatechin loaded phytosomes exhibitedpromising results and warrant further in vitro andin vivo investigations under a set of stringentparameters for transforming in to a clinically viable products.