Open AccessDecreased Blood Glucose and Histopathology Improvement in Hyperbaric Hyperoxic Conditions Alloxan-induced rats(Laboratory Experimental Study)
Author(s) -
Retno Budiarti
Publication year - 2019
Publication title -
international journal of pharmtech research
Language(s) - English
Resource type - Journals
eISSN - 2455-9563
pISSN - 0974-4304
DOI - 10.20902/ijptr.2019.120408
Subject(s) - alloxan , histopathology , hyperbaric oxygen , medicine , blood sugar , pancreas , diabetes mellitus , physiology , endocrinology , gastroenterology , pathology , surgery
Background: Diabetes mellitus is still a problem in Indonesia, related to thenumber of organs involved. This disease has relatively high morbidity and mortality rates.Adjuvant therapy is needed considering the long-term therapy that must be consumed bypatients. Objective: To explain the effect of hyperbaric oxygen in reducing blood glucoselevels, and repairing histopathological damage to the pancreas and liver. Method : this studywas an experimental laboratory study using whistar strain rats (Rattus Norvegicus) which weregiven a normal diet then induced alloxan to create a hyperglycemia condition. After that, 12rats from the treatment group were given 3 x 30’ hyperbaric oxygen exposure for 6 days. Bloodglucose levels, histopathological changes in the pancreas and liver was measured between thetreatment group and the control group were not given hyperbaric oxygen exposure. Results:There was a significant difference (α< 0,05) in decreasing blood glucose and repairinghistopathological damage in pancreatic and liver tissue between treated group and controlgroup. Conclusion: hyperbaric oxygen treatment as much as 3 x 30'for days at 2.4 ATA O2100% reduce blood glucose levels and repair histopathological damage to pancreatic tissue andliver of alloxan- induced white rats.