Open AccessDevelopment and Validation of UV Spectrophotometric Method for the Estimation of Cilnidipine and Valsartan in Bulk and Pharmaceutical Formulations
Author(s) -
Deshmukh Madhuri D,
Deshmukh Supriya D
Publication year - 2019
Publication title -
international journal of pharmtech research
Language(s) - English
Resource type - Journals
eISSN - 2455-9563
pISSN - 0974-4304
DOI - 10.20902/ijptr.2019.120406
Subject(s) - valsartan , dosage form , chromatography , solvent , correlation coefficient , chemistry , mathematics , medicine , statistics , organic chemistry , blood pressure , radiology
A simple, rapid, accurate, precise, specific and economical spectrophotometricmethod for simultaneous estimation of Cilnidipine and Valsartan in combined tablet dosageform has been developed. Its employs Formation and solving of simultaneous equation usingtwo wavelengths 240.20nm and 250nm using methanol as solvent. This method obeys Beerslaw in the employed concentration range 2-12μg /mL and 8-40 μg /mL for Cilnidipine andValsartan respectively. Coefficient of correlation (R2) was 0.999for Cilnidipine and 0.999 forValsartan. This method can be adopted in routine analysis of Cilnidipine and Valsartan in bulkand tablet dosage form and it involves relatively low cost solvent and no complex extractiontechnique.