Open AccessThermodynamic Studies of Complexes of Amlodipine Besylate with Ni2+, Mg2+, Co2+ and Ca2+ cations in pure and in mixed binary solvent systems at 303.15, 313.15 and 323.15 K by Conductometric Method
Author(s) -
Dhruvi R. Mehta,
Raviprakash S. Chandra,
M. M. Maisuria
Publication year - 2020
Publication title -
international journal of chemtech research
Language(s) - English
Resource type - Journals
eISSN - 2455-9555
pISSN - 0974-4290
DOI - 10.20902/ijctr.2019.130125
Subject(s) - chemistry , solvent , enthalpy , stoichiometry , conductance , metal , stability constants of complexes , inorganic chemistry , thermodynamics , aqueous solution , organic chemistry , physics , mathematics , combinatorics
The present work relates to the complexation reaction between AmlodipineBesylate[AML] with Ni2+, Mg2+, Co2+ and Ca2+ cation in dimethylsulfoxide (DMSO), puremethanol (MeOH) and their binary mixtures(DMSO-MeOH and DMSO-Water) byconductometric method. The conductance data show that the stoichiometry of the complexesformed between AML with Ni2+, Mg2+, Co2+ and Ca2+ cation in pure DMSO, pure MeOHaswell as in the binary solvent mixtures was 1:1. The stability of AML complexes with Ni2+,Mg2+, Co2+ and Ca2+ metal ion was observed to be sensitive to the nature of the solventsystem. In case of DMSO-Water binary solvent systems there was a linear change in LogKfvalues but in case of DMSO-MeOH binary solvent systems non linear change in LogKfvalues observed.The negative values of ΔG0show that the reaction is spontaneous and abilityof the AML ligand to form stable complexes. However, the result shows positive value ofΔH0 which indicates that enthalpy is not driving force for the formation of the complexes.Furthermore, the positive value of ΔS0indicates that entropy is a driving force for thecomplexation. The values of ΔH0and ΔS0for formation of the complexes were obtainedfrom temperature dependence of the stability constants.