Open AccessSynthesis and SAR Evaluation of Mercaptotriazolo derivatives as anti-inflammatory agents.
Author(s) -
S Mamatha,
S. L. Belagali,
Mahesh Bhat
Publication year - 2020
Publication title -
international journal of chemtech research
Language(s) - English
Resource type - Journals
eISSN - 2455-9555
pISSN - 0974-4290
DOI - 10.20902/ijctr.2019.130123
Subject(s) - benzothiazole , moiety , substituent , chemistry , pyrrolidine , ring (chemistry) , stereochemistry , molecule , chemical structure , carbon 13 nmr , anti inflammatory , combinatorial chemistry , organic chemistry , pharmacology , medicine
A new series of benzothiazole appended triazole derivatives were synthesized.Characterization is done by FT-IR, Mass, 1H and 13C NMR spectroscopic techniques. Thenewly synthesized compounds were screened for antioxidant and anti inflammatory activities.Experimental data hypothesized compound 7b as highly potent cytotoxicant with lengthenedactivity. Structure–activity relation interrelates the biological activity and chemical moiety ofthe molecule. Structurally, 7b is a benzothiazolyltriazole having a pyrrolidine group (fivemembered ring) attached to two CH2 groups and methyl substituent at 7th position of thebenzothiazole ring