Open AccessProtection of Renal Function ByHyperbaric OxygenDuring Plasmodium berghei ANKA Infection
Author(s) -
Prawesty Diah Utami,
Herin Setianingsih
Publication year - 2020
Publication title -
international journal of chemtech research
Language(s) - English
Resource type - Journals
eISSN - 2455-9555
pISSN - 0974-4290
DOI - 10.20902/ijctr.2019.130108
Subject(s) - artesunate , creatinine , blood urea nitrogen , plasmodium berghei , renal function , medicine , malaria , gastroenterology , pharmacology , plasmodium falciparum , immunology
Background:Malaria cases have consistently increased and the number of deathsremains largely unchanged.Malaria associated renal injury has a high level of morbidity andmortality. High level of blood urea nitrogen / BUN and plasma creatinine is one of the majorfactors associated with mortality in humans infected with malaria, indicating that impairment ofrenal function. HBO is widely used as an adjunctive therapy for many diseases, it is known thatHBO hasan action as antiplasmodium, antiinflammation and antioxidant effects.Objective: The aim of this study was to determine the effect of HBO on BUN and creatininelevels in rats infected with P. berghei ANKA.Methods:This research was conducted experimentally post-test only control group on sixgroups of rats. The samples used were 24 male Rattus norvegicus wistar strain that have beeninfected by Plasmodium bergheiANKA and divided into 6 groups. Group 1 was givencombination artesunate and 1, 5 ATA HBO, grup 2 was given combination artesunate and 3, 0ATA HBO, group 3 was given 1, 5 ATA HBO, group 4 was given 3, 0 ATA HBO, group 5 wasgiven artesunate and group 6 was given aquadest. HBO therapy is carried out for 10 days andthe observation of the levels of BUN and creatinine in mice after treatment on tenth day.Results:Descriptive analysis and statistical analysis (Kruskal wallis snd Mann whitney Uposthoc) showed a significant difference (p < α = 0.05) on mean levels of BUN and creatininegroup receiving combination of artesunate and HBO 3,0 ATA compared to othergroups.Hyperbaric oxygen has the effect of reducing the levels of BUN and creatinine in ratsinfected by P.berghei ANKA.