Development & Validation of HPLC method for simultaneous estimation of Drotaverine & Omeprazole | Zendy

Zaheer Shaikh | Zendy; Abdul Ahad | Zendy; Showkat Patel | Zendy; Maqdoom Farooqui | Zendy

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Development & Validation of HPLC method for simultaneous estimation of Drotaverine & Omeprazole

Author(s) -

Zaheer Shaikh,

Abdul Ahad,

Showkat Patel,

Maqdoom Farooqui

Publication year - 2020

Publication title -

international journal of chemtech research

Language(s) - English

Resource type - Journals

eISSN - 2455-9555

pISSN - 0974-4290

DOI - 10.20902/ijctr.2019.130101

Subject(s) - chromatography , omeprazole , chemistry , high performance liquid chromatography , potassium , acetonitrile , potassium phosphate , selectivity , pharmacology , catalysis , biochemistry , organic chemistry , medicine

A simple and accurate method was developed for simultaneous estimation ofDrotaverine & Omeprazole. The chromatography parameters includes stainless steel column Develosil ODS HG-5 RP C18, 5m, 15cmx4.6mm i.d and acetonitrile: potassium dihydrogen phosphate buffer (0.02M, pH 3.0) (55:45v/v) as mobile phase at a flow rate (1.0 ml/minute). The determinations were performed using UV-Vis detector set at 273 nm. The developed HPLC method showed specificity and selectivity with good precision and accuracy, which makes it very suitable for quantification of Drotaverine & Omeprazole.

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