Open AccessCognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies
Author(s) -
Xianjin Zhou
Publication year - 2021
Publication title -
journal of psychiatry and brain science
Language(s) - English
Resource type - Journals
ISSN - 2398-385X
DOI - 10.20900/jpbs.20210009
Subject(s) - autoantibody , immunology , medicine , cognition , antibody , population , epitope , titer , psychiatry , environmental health
Antibodies persist months and years in blood. Chronic presence of low titers of blood circulating anti-NMDAR1 autoantibodies are sufficient to impair cognitive function in the integrity of the BBB in mice, suggesting potential cognitive damaging effects of low titers of blood circulating anti-NMDAR1 autoantibodies in the general human population and psychiatric patients. Investigation of anti-NMDAR1 autoantibodies against individual NMDAR1 antigenic epitopes may potentially provide risk biomarkers and therapeutic targets for development of immunotherapy as a precision medicine for psychiatric patients in the future.