Open AccessHungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food
Author(s) -
Marie–Dominique Filippi
Publication year - 2022
Publication title -
immunometabolism
Language(s) - English
Resource type - Journals
ISSN - 2633-0407
DOI - 10.20900/immunometab20220011
Subject(s) - cd36 , haematopoiesis , stem cell , hematopoietic stem cell , fatty acid , biology , downregulation and upregulation , beta oxidation , long chain fatty acid , biochemistry , microbiology and biotechnology , gene
Hematopoietic stem cells (HSC) directly initiate a response to bacterial infections by rapidly entering the cell cycle in order to produce mature blood cells. An important issue in the field of HSC biology is to understand how metabolic activities of HSC are fueled during specific condition that require HSC activation. In their paper, Mistry et al. provide evidence that bacterial infections trigger an increased in free fatty acid uptake by HSC that fuel fatty acid oxidation and mitochondrial respiration activities. This increased fatty acid uptake is exclusively dependent on the upregulation of the fatty acid transporter CD36. This study shed important light into the metabolic needs of HSC during septic conditions.