Open AccessMyeloid Metabolism as a New Target for Rejuvenation?-Comments on Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Ageing. Nature. 2021 Feb;590(7844)122-128
Author(s) -
Marlen Knobloch,
Rosa Chiara Paolicelli
Publication year - 2021
Publication title -
immunometabolism
Language(s) - English
Resource type - Journals
ISSN - 2633-0407
DOI - 10.20900/immunometab20210034
Subject(s) - myeloid cells , cognitive decline , ageing , myeloid , neuroscience , cognition , immune dysfunction , immune system , biology , rejuvenation , medicine , psychology , gerontology , immunology , dementia , disease
Research led by Katrin Andreasson suggests that fixing age-induced metabolic defects in myeloid cells would suffice to reverse cognitive impairment and to restore synaptic plasticity to the level of young subjects, at least in mice. This opens up the possibility to develop rejuvenating strategies by targeting immune dysfunction.