Open AccessA Single Human-Relevant Fast Food Meal Rapidly Reorganizes Metabolomic and Transcriptomic Signatures in a Gut Microbiota-Dependent Manner#
Author(s) -
Lucas J Osborn,
Danny Orabi,
Maryam Goudzari,
Naseer Sangwan,
Rakhee Banerjee,
Amanda Brown,
Anagha Kadam,
Anthony D. Gromovsky,
Pranavi Linga,
Gail Cresci,
Tytus D. Mak,
Belinda Willard,
Jan Claesen,
J. Mark Brown
Publication year - 2021
Publication title -
immunometabolism
Language(s) - English
Resource type - Journals
ISSN - 2633-0407
DOI - 10.20900/immunometab20210029
Subject(s) - gut flora , metabolomics , biology , transcriptome , microbiome , meal , metabolome , liver disease , gut–brain axis , physiology , immunology , gene , bioinformatics , food science , genetics , gene expression , biochemistry
A major contributor to cardiometabolic disease is caloric excess, often a result of consuming low cost, high calorie fast food. Studies have demonstrated the pivotal role of gut microbes contributing to cardiovascular disease in a diet-dependent manner. Given the central contributions of diet and gut microbiota to cardiometabolic disease, we hypothesized that microbial metabolites originating after fast food consumption can elicit acute metabolic responses in the liver.