Open AccessMitochondrial Calcification
Author(s) -
Bhargavi Duvvuri,
Christian Lood
Publication year - 2021
Publication title -
immunometabolism
Language(s) - English
Resource type - Journals
ISSN - 2633-0407
DOI - 10.20900/immunometab20210008
Subject(s) - calcification , mitochondrion , calcium , microbiology and biotechnology , biology , chemistry , biochemistry , pathology , medicine , organic chemistry
One of the most fascinating aspects of mitochondria is their remarkable ability to accumulate and store large amounts of calcium in the presence of phosphate leading to mitochondrial calcification. In this paper, we briefly address the mechanisms that regulate mitochondrial calcium homeostasis followed by the extensive review on the formation and characterization of intramitochondrial calcium phosphate granules leading to mitochondrial calcification and its relevance to physiological and pathological calcifications of body tissues.