Open AccessSingle-cell trajectories of melanoma cell resistance to targeted treatment
Author(s) -
Michael Schmidt,
Lena Sünke Mortensen,
Henry LoefflerWirth,
Corinna Kosnopfel,
Knut Krohn,
Hans Binder,
Manfred Kunz
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - English
Resource type - Journals
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2021.0267
Subject(s) - vemurafenib , melanoma , trametinib , biology , reprogramming , cancer research , mek inhibitor , transcriptome , cell , computational biology , kinase , microbiology and biotechnology , mapk/erk pathway , genetics , gene , gene expression , metastatic melanoma
Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant melanoma. Recent developments in single-cell sequencing technology have provided deeper insights into these mechanisms.