Open AccessHypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer
Author(s) -
Hongxia Sun,
Danfang Zhang,
Chongbiao Huang,
Yuhong Guo,
Yupei Zhao,
Nan Yao,
Xueyi Dong,
Run-Fen Cheng,
Nan Zhao,
Jie Meng,
Bei Sun,
Jihui Hao
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - English
Resource type - Journals
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2021.0158
Subject(s) - transcriptome , hypoxia (environmental) , biology , cancer research , pancreatic cancer , tumor microenvironment , metastasis , tumor hypoxia , cancer , gene , medicine , gene expression , genetics , radiation therapy , tumor cells , chemistry , oxygen , organic chemistry
Hypoxia is a significant feature of solid tumors, including pancreatic ductal adenocarcinoma (PDAC). It is associated with tumor invasion, metastasis, and drug resistance. However, the spatial distribution of hypoxia-related heterogeneity in PDAC remains unclear.