Open AccessThe m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma
Author(s) -
Hua Ye,
Tianqi Chen,
Zhan-Cheng Zeng,
Bo He,
Qianqian Yang,
Qi Pan,
Wen-Tao Wang
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.517
H-Index - 42
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2020.0661
Subject(s) - gene knockdown , chromatin immunoprecipitation , stat3 , carcinogenesis , biology , cancer research , cell growth , microbiology and biotechnology , signal transduction , cell culture , cancer , gene , gene expression , genetics , promoter
Investigation of the regulatory mechanisms of cell stemness in cholangiocarcinoma (CCA) is essential for developing effective therapies to improve patient outcomes. The purpose of this study was to investigate the function and regulatory mechanism of m6A modifications in CCA cell stemness.