Open AccessSystematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells
Author(s) -
Yu Yu,
Minzhen Tao,
Le Xu,
Lei Cao,
Baoyu Le,
Na An,
Jilin Dong,
Ya-Jie Xu,
Baoxing Yang,
Wei Li,
Bing Liu,
Qiong Wu,
Yinying Lu,
Zhen Xie,
Xiaohua Lian
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - English
Resource type - Journals
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2020.0560
Subject(s) - biology , lgr5 , cancer research , cancer , cancer cell , computational biology , genetics , bioinformatics , cancer stem cell
Effective adjuvant therapeutic strategies are urgently needed to overcome MAPK inhibitor (MAPKi) resistance, which is one of the most common forms of resistance that has emerged in many types of cancers. Here, we aimed to systematically identify the genetic interactions underlying MAPKi resistance, and to further investigate the mechanisms that produce the genetic interactions that generate synergistic MAPKi resistance.