Open AccessTranscription factor-based gene therapy to treat glioblastoma through direct neuronal conversion
Author(s) -
Xin Wang,
Zifei Pei,
Aasma Hossain,
Y. Bai,
Chen Gong
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.517
H-Index - 42
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2020.0499
Subject(s) - transcription factor , biology , cancer research , reprogramming , glioma , neural stem cell , cell , microbiology and biotechnology , transcriptome , stem cell , gene , gene expression , genetics
Glioblastoma (GBM) is the most prevalent and aggressive adult primary cancer in the central nervous system. Therapeutic approaches for GBM treatment are under intense investigation, including the use of emerging immunotherapies. Here, we propose an alternative approach to treat GBM through reprogramming proliferative GBM cells into non-proliferative neurons.