Open AccessThree-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas
Author(s) -
Giacomo Miserocchi,
Claudia Cocchi,
Alessandro De Vita,
Chiara Liverani,
Chiara Spadazzi,
Sebastiano Calpona,
Grazia Menna,
Massimo Bassi,
Giuseppe Meccariello,
Giovanni De Luca,
Angelo Campobassi,
Maria Maddalena Tumedei,
Alberto Bongiovanni,
Valentina Fausti,
Franco Cotelli,
Toni Ibrahim,
Laura Mercatali
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.517
H-Index - 42
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2020.0482
Subject(s) - tumor microenvironment , extracellular matrix , cancer research , 3d cell culture , cell culture , angiogenesis , cell , biology , epithelial–mesenchymal transition , microbiology and biotechnology , chemistry , cancer , metastasis , genetics , tumor cells
Squamous cell carcinoma (SCC) represents the most common histotype of all head and neck malignancies and includes oropharyngeal squamous cell carcinoma (OSCC), a tumor associated with different clinical outcomes and linked to human papilloma virus (HPV) status. Translational research has few available in vitro models with which to study the different pathophysiological behavior of OSCCs. The present study proposes a 3-dimensional (3D) biomimetic collagen-based scaffold to mimic the tumor microenvironment and the crosstalk between the extracellular matrix (ECM) and cancer cells.