Open AccessCUL4B facilitates HBV replication by promoting HBx stabilization
Author(s) -
Haixia Shan,
Bo Wang,
Xiaodong Zhang,
Hui Song,
Xi Li,
Yongxin Zou,
Baichun Jiang,
Huili Hu,
Haoran Dou,
Changshun Shao,
Lifen Gao,
Chao Ma,
Xiaoyun Yang,
Xiaohong Liang,
Yaoqin Gong
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2020.0468
Subject(s) - hbx , gene knockdown , hepatitis b virus , ubiquitin , ubiquitin ligase , immunoprecipitation , biology , viral replication , virology , cancer research , microbiology and biotechnology , cell culture , virus , gene , genetics
Hepatitis B virus (HBV) infection is a major public health problem worldwide. However, the regulatory mechanisms underlying HBV replication remain unclear. Cullin 4B-RING ubiquitin E3 ligase (CRL4B) is involved in regulating diverse physiological and pathophysiological processes. In our study, we aimed to explain the role of CUL4B in HBV infection.