Open AccessDrug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network
Author(s) -
Xi Cheng,
Wenyu Zhao,
Mengdi Zhu,
Bo Wang,
Xuege Wang,
Xiaoyun Yang,
Yuqi Huang,
Minjia Tan,
Jing Li
Publication year - 2021
Publication title -
cancer biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.517
H-Index - 42
ISSN - 2095-3941
DOI - 10.20892/j.issn.2095-3941.2020.0218
Subject(s) - drug repositioning , repurposing , prostate cancer , drugbank , drug , cancer , drug discovery , medicine , pharmacology , computational biology , computer science , bioinformatics , biology , ecology
Drug repurposing, the application of existing therapeutics to new indications, holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug development. The aim of our study was to perform a more comprehensive drug repurposing prediction of diseases, particularly cancers.