Open AccessIsolation of alkaloids compound of ethanol extract of mangrove perepat (S. alba) root and its antibacterial activity
Author(s) -
Madyawati Latief,
Muhaimin Muhaimin,
Hilda Amanda,
Indra Lasmana Tarigan,
Siti Aisyah
Publication year - 2021
Publication title -
jurnal ilmiah farmasi
Language(s) - English
Resource type - Journals
ISSN - 1693-8666
DOI - 10.20885/jif.vol17.iss1.art2
Subject(s) - alkaloid , antibacterial activity , phytochemical , mangrove , traditional medicine , chemistry , ethanol , agar diffusion test , botany , bacteria , biology , organic chemistry , medicine , ecology , genetics
Background: Exploration of the chemical contents and bioactivities of mangrove plants is important to discover new therapeutic agents for society and to develop its medicinal values. Objective: This study aims to isolate alkaloid compounds from the ethanol extract of Sonneratia alba root which is likely to have an antibacterial activity. Methods: Isolation was carried out using fractionation and chromatography, while antibacterial activity test was performed using the disc diffusion methods. Results: Our phytochemical screening shows that the ethanol extract has a high concentration of alkaloid compounds. The alkaloid which contain in isolate (F4) is further confirmed through UV-Vis Spectra and FT-IR spectra. The ethanol extract exhibits the antibacterial activity against S. aureus and E. coli with the inhibition zone of 1.5 mm and 2.5 mm, respectively. Conclusion: Alkaloid compound has been isolated from Sonneratia alba and has potential as antibacterial agent. Keywords: mangrove perepat (Sonneratia alba), alkaloid, antibacterial agent