Open AccessSINTESIS DAN UJI AKTIVITAS ANALGETIKA-ANTIINFLAMASI SENYAWA N-(4t-butilbenzoil)-p-aminofenol
Author(s) -
Sri Sutji Susilowati,
Siti Ragil Handayani
Publication year - 2006
Publication title -
molekul
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 2
eISSN - 2503-0310
pISSN - 1907-9761
DOI - 10.20884/1.jm.2006.1.1.21
Subject(s) - ed50 , analgesic , chemistry , melting point , edema , chloride , nuclear chemistry , chromatography , pharmacology , organic chemistry , medicine , in vitro , surgery , biochemistry
The synthesis of N-4t-butyl benzoil-p-aminophenol has been done by reacting p-aminophenol and N-4t-butyl benzoil chloride compounds, then the products were isolated and analyzed by TLC, melting point determination, UV/Vis Spectrofotometry, infra red spectrofotometry and mass spectrometry. The synthesis yield of N-4t-butylbenzoil-p-aminophenol was 33,52%, with the compound melting point between 192-194 oCThe determination of analgesic (ED50 of % analgesic activity ) and anti inflammatory activity (ED50 of edema inhibition) gave the ED50 of % analgesic activity was 144 mg/kg and ED50 of % edema inhibition was 43,24 mg/kg.