SINTESIS DAN UJI AKTIVITAS ANALGETIKA-ANTIINFLAMASI SENYAWA N-(4t-butilbenzoil)-p-aminofenol | Zendy

Sri Sutji Susilowati | Zendy; Santi Nur Handayani | Zendy

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SINTESIS DAN UJI AKTIVITAS ANALGETIKA-ANTIINFLAMASI SENYAWA N-(4t-butilbenzoil)-p-aminofenol

Author(s) -

Sri Sutji Susilowati,

Santi Nur Handayani

Publication year - 2006

Publication title -

molekul

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 2

eISSN - 2503-0310

pISSN - 1907-9761

DOI - 10.20884/1.jm.2006.1.1.21

Subject(s) - ed50 , analgesic , melting point , chemistry , edema , chloride , nuclear chemistry , chromatography , yield (engineering) , medicinal chemistry , pharmacology , organic chemistry , medicine , surgery , in vitro , biochemistry , materials science , metallurgy

The synthesis of N-4t-butyl benzoil-p-aminophenol has been done by reacting p-aminophenol and N-4t-butyl benzoil chloride compounds, then the products were isolated and analyzed by TLC, melting point determination, UV/Vis Spectrofotometry, infra red spectrofotometry and mass spectrometry. The synthesis yield of N-4t-butylbenzoil-p-aminophenol was 33,52%, with the compound melting point between 192-194 oCThe determination of analgesic (ED50 of % analgesic activity ) and anti inflammatory activity (ED50 of edema inhibition) gave the ED50 of % analgesic activity was 144 mg/kg and ED50 of % edema inhibition was 43,24 mg/kg.

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