Open AccessCurrent directions in searching for tuberculostatic substances
Author(s) -
Justyna Żwawiak,
Lucjusz Zaprutko
Publication year - 2014
Publication title -
journal of medical science
Language(s) - English
Resource type - Journals
eISSN - 2353-9801
pISSN - 2353-9798
DOI - 10.20883/medical.e58
Subject(s) - drug , tuberculosis , regimen , heading (navigation) , first line , second line , medicine , intensive care medicine , pharmacology , surgery , pathology , geography , geodesy
Yearly, 8 milion people advance to active tuberculosis (TB) and nearly 2 milion victims die of their infection. Long drug regimen is blamed for the emergence of drug resistant TB. Moreover, 20% of TB isolates are already resistant to the first line antituberculosis drugs. This situation has required to develop new, more active anti-TB substances. Several novel drug candidates from different groups of chemical compounds undergo clinical trials. Others, also promising agents, have been obtained recently. They are the basis for further modifications heading for improvement of their physicochemical, biological and toxicological parameters.