Open AccessCervical expression of elafin and secretory leukocyte peptidase inhibitor does not predict preterm delivery in twin pregnancy – results from a pilot study
Author(s) -
Aleksandra Saletra-Bielińska,
Katarzyna Kosińska–Kaczyńska,
Iwona Szymusik,
Justyiderla-Bielińska,
Jacek Malejczyk,
Mirosław Wielgoś
Publication year - 2021
Publication title -
journal of medical science
Language(s) - English
Resource type - Journals
eISSN - 2353-9801
pISSN - 2353-9798
DOI - 10.20883/medical.e490
Subject(s) - elafin , slpi , gestation , medicine , gestational age , twin pregnancy , pregnancy , obstetrics , prospective cohort study , andrology , immunology , biology , inflammation , genetics
Background. Elafin and secretory leukocyte peptidase inhibitor may serve as the predictors of cervical shortening and preterm delivery in twin gestation.Material and Methods. A prospective observational study was conducted between September 2016 and March 2017. Cervicovaginal swabs collected from 40 women with twin gestation were analysed and the mRNA expression of elafin and secretory leukocyte peptidase inhibitor (SLPI) correlated with preterm delivery.Results. The mean gestational age at delivery was 35.6 ± 5.8 weeks, with 23 women delivering before 37 weeks (57.5%), 7 before 34 weeks (17.5%) and 3 before 32 weeks of gestation (7.5%). The mRNA expression of elafin and SLPI was not dependent on chorionicity and did not correlate with gestational age at delivery.Conclusions. Elafin and SLPI are not appropriate predictors of preterm delivery in twins.