Open AccessMitochondrial DNA as DAMP in critical conditions
Author(s) -
Е. В. Григорьев,
Р. Р. Салахов,
М. В. Голубенко,
А. В. Понасенко,
Д. Л. Шукевич,
В. Г. Матвеева,
А. С. Радивилко,
А. В. Цепокина,
Е. А. Великанова,
Р. А. Корнелюк,
А. А. Ивкин
Publication year - 2019
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2019-3-134-143
Subject(s) - mitochondrial dna , damp , immune system , inflammation , inflammatory response , mitochondrion , biology , immunology , pathological , homeostasis , genome , neuroscience , genetics , bioinformatics , microbiology and biotechnology , medicine , gene , pathology , meteorology , physics
The focus of the researchers’ attention today includes the recently discovered role of mitochondria in the immune response. Increasing evidence shows that mitochondrial DNA, in retaining some of their characteristics of the ancient α-proteobacteria’s genome, is a potent immune stimulus for inflammatory reactions. Systemic inflammatory response is a frequent complication in surgical interventions and various traumas, and its development cannot be explained using common conceptions. This review provides information on the current understanding of the development of inflammation mediated by mtDNA, including systemic inflammatory response, and on the mechanisms regulating mitochondrial homeostasis and mtDNA release in various pathological conditions.