Open AccessInduced immunosuppression in critical care: diagnostic opportunities in clinical practice
Author(s) -
Е. В. Григорьев,
В. Г. Матвеева,
Д. Л. Шукевич,
А. С. Радивилко,
Е. А. Великанова,
М. Ю. Ханова
Publication year - 2019
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2019-1-18-29
Subject(s) - immunosuppression , immunology , inflammation , immune system , systemic inflammation , medicine
The immune system in critical illnesses initiates local inflammation in the damaged area. In the absence of a balance between local and systemic inflammations, an infectious or non-infectious systemic inflammatory response follows, which has a stage of "hyper inflammation - compensatory anti-inflammatory response", that may result in multi-organ failure. The final stage of critical ill-nesses, therefore, will be characterized by induced immunosuppression with the impaired function of neutrophils, monocytes, macrophages and dendritic cells and release of myeloid-derived suppres-sor cells. The aim of the review is to evaluate the contribution of various components of the im-mune response to the formation of induced immune suppression from the perspective of candidate diagnostic markers.