Open AccessAllelic variants of human genes affecting HIV intracellular life cycle and regulating immune response to HIV infection
Author(s) -
Р. М. Хаитов,
L. Alexeev,
Г.О. Гудима,
И.А. Кофиади
Publication year - 2019
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2019-1-119-130
Subject(s) - gene , biology , immune system , viral replication , virology , human immunodeficiency virus (hiv) , human leukocyte antigen , intracellular , genetics , immunology , virus , antigen
Host genetic factors influencing the intracellular part of HIV live cycle and regulating of HIV-specific immune response are reviewed. Its include genes coding proteins which support viral replication and assembly of new virions, genes coding antiviral defense proteins, HLA genes and some others. Variants of these genes and its compositions affect individual succeptibility/resistance to HIV infection, influence the pathogenesis of the disease and also associate with efficacy of antiretroviral therapy.