Open AccessMOLECULAR GENETIC STUDIES OF COMORBIDITY
Author(s) -
Elena Bragina,
Maxim B. Freidin
Publication year - 2015
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2015-6-94-102
Subject(s) - comorbidity , disease , computational biology , biology , complex disease , genome wide association study , gene , genetics , single nucleotide polymorphism , phenotype , bioinformatics , medicine , psychiatry , genotype , pathology
This review focuses at the problem of the genetic basis of comorbidity. We discuss the concepts and terms relating to combinations of diseases. The guidelines of the study of comorbidity using modern high throughput methods and approaches of genetics, molecular biology and bioinformatics are designated. In this review we present results of studies showing genetic specificity for the combined phenotypes dif-ferent from the isolated disease, we considergene-gene and gene-environment interactions in comorbidity. We also discuss the role of single nucleotide polymorphisms and structural genome variations in the development of comorbidity. Own results of researching shared genes of inversely comorbid diseases like as bronchial asthma and tuberculosis are presented.