Open AccessDEVIATIONS IN MENTAL DEVELOPMENT OF THE OFFSPRING OF RATS WITH EXPERIMENTAL PREECLAMPSIA AND THEIR CORRECTION BY NEW DERIVATIVE OF GAMMA-AMINOBUTYRIC ACID
Author(s) -
Иван Николаевич Тюренков,
В. Н. Перфилова,
Л. І. Михайлова,
Гульнара Александровна Жакупова,
С. А. Лебедева
Publication year - 2014
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2014-3-56-62
Subject(s) - offspring , open field , preeclampsia , derivative (finance) , gamma aminobutyric acid , pregnancy , gestation , psychology , medicine , endocrinology , chemistry , biology , receptor , genetics , financial economics , economics
The aim of investigation was to study the effect of a gamma-aminobutyric acid´s derivative – a compound RGPU-242 – on the mental development of the rat´s offspring with experimental preeclampsia. Famels’s preeclampsia was modeled by replacing the drinking water of 1.8% sodium chloride solution from 7th to the 21th day of gestation. Locomotion, indicative and emotional activity and cognitive functions in progeny were recorded on “Open field”, “One-way step-down inhibitory (“passive”) avoidance”, “Elevated plus maze” and “Test of extrapolative escape” tests in different periods of postnatal development. Found that the compound RGPU-242 has gravidoprotective effect, improves formation and development of mental functions in the offspring.