Open AccessINVESTIGATION OF NEUROPROTECTIVE ACTIVITY THIOPHANE INVOLUTIONAL CHORIORETINAL DEGENERATION IN RATS OXYS
Author(s) -
А. А. Жданкина,
George Armand Robert Kon,
М. Б. Плотников,
Е. Ю. Варакута,
С. В. Логвинов,
А. Е. Просенко,
Н.Г. Колосова
Publication year - 2013
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2013-3-24-32
Subject(s) - neuroprotection , retina , retinal , macular degeneration , retinal degeneration , chemistry , antioxidant , chemiluminescence , endocrinology , medicine , ophthalmology , biology , biochemistry , neuroscience , chromatography
The method of spontaneous and induced luminol -dependent chemiluminescence in homogenates of rat retinas OXYS registered increase in the generation of free radicals against decrease in total antioxidant activity. With the ultra-microscopic and quantitative analysis revealed degenerative retinal neurons rats OXYS: the percentage increase in neurosensory cells with pyknosis of nuclei, hyperchromatic piknomorfnyh associative neurons and ganglion n eurons that have been modified on a light and dark type. Thiophane, limiting free radical reactions in the retina and protects retinal neurons from damage.