Open AccessFEATURES KALLIKREIN-KININ SYSTEMS AND DYSFUNCTIONS ENDOTHELIUM AT NEWBORNS WITH HYPOXEMIC DEFEAT OF THE CENTRAL NERVOUS SYSTEM
Author(s) -
В. А. Желев,
Анна Сергеевна Погудина,
В.В. Горев
Publication year - 2013
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2013-3-106-110
Subject(s) - kallikrein , central nervous system , hypoxia (environmental) , kinin , encephalopathy , medicine , pathological , endocrinology , neuroscience , biology , bradykinin , chemistry , oxygen , receptor , biochemistry , enzyme , organic chemistry
Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions. 201 prematurely newborn of various degree gestation with hypoxemic affection of the central nervous system were under observation. We have studied the activity of kallikrein, kallikreinogen in newborns with hypoxic-ischemic encephalopathy. The activity of the kallikrein-kinin system was increased in all the groups against the background of the decreased inhibitory activity of blood plasma of different intensity, which can be used for the prediction of the course of diseases.