Open AccessCurrent approaches to development of contrast agents for MRI diagnostics
Author(s) -
К. Н. Сорокина,
А. А. Тулупов,
Т. Г. Толстикова,
Владимир Юрьевич Усов
Publication year - 2011
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2011-6-79-85
Subject(s) - magnetic resonance imaging , contrast (vision) , medicine , nanotechnology , computer science , radiology , materials science , artificial intelligence
Magnetic resonance imaging (MRI) is primarily used in medical imaging to visualize the structure and function of the body and essential tool for diagnostics of broad range of pathologies. But still in a growing number of cases there are indications to use contrast agent to delineate areas of interest and for more precise diagnosis definition. In a review the properties and clinical applications of most popular paramagnetic contrast agents based on Gd(III), Fe(II) и Mn(II) are discussed. It is also focused on discussion of modern experimental targeted contrast agents (conjugates of antibodies, nanoparticles and dendrimers) and advances of their application for early diagnostics of most common pathologies: cardiovascular, cancer and Alzheimer diseases.