Open AccessThe role of intracellular gaseous transmitters hydrogen sulfide and nitric oxide in apoptosis regulation of normal and cancer cells
Author(s) -
Ye. G. Starikova,
N. V. Ryazantsevа,
V. V. Novitsky,
L. A. Tashireva,
Yu. V. Starikov,
E. A. Stepovaya,
I. A. Osikhov,
O. A. Vasiliyeva,
Y. D. Yakushina
Publication year - 2011
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2011-6-40-44
Subject(s) - jurkat cells , hydrogen sulfide , apoptosis , nitric oxide , incubation , chemistry , programmed cell death , necrosis , peripheral blood mononuclear cell , intracellular , microbiology and biotechnology , immunology , biochemistry , biology , medicine , t cell , in vitro , organic chemistry , sulfur , immune system
Investigation of influence of gases nitric oxide and hydrogen sulfide on apoptotic cell death of Jurlat cells and mononuclear leucocytes of healthy donors was conducted. It was shown that 100 mmol sodium nitroprussidi increased the apoptosis of T lymphoblast leukemia cells after 15’ incubation. 10 and 100 mmol donor of hydrogen sulfide caused apoptotic death of Jurkat cells after 15’ incubation. 15’ exposure of nitric oxide and hydrogen sulfide donors did not lead to the changes of cell death of mononuclear leucocytes. Gaseous transmitters NO and H2S increased necrosis of Jurkat cells and mononuclear leucocytes after 24 h incubation with the appropriate gase’s donor.