Open AccessSanogenetic mechanisms of transplantation action of the whole cells and their nuclear fraction on experimental dislipoproteinemia model
Author(s) -
Yu. I. Pivovarov,
T. Ye. Kurilskaya,
A. S. Sergeyeva,
I. V. Babushkina,
B. K. Baduyev,
G. B. Borovsky
Publication year - 2011
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2011-6-23-29
Subject(s) - transplantation , nucleus , apoptosis , aorta , cell , biology , cell nucleus , chemistry , microbiology and biotechnology , pathology , cancer research , medicine , biochemistry
Research objective was to compare effects of transplantation of cells and their nucleus on model alimentary dislipoproteinemia. Experiment is executed on the rabbits containing on an atherogenous diet. In blood serum of animals studied changes of a lipide exchange, in a liver — level of stresses-proteins, morphological changes and the maintenance of markers of an apoptosis and a proliferation. Also estimated the area of atherogenous plaques and a thickness of intima of an aorta. It is shown that unlike cellular transplantation, introduction of nucleus led to more expressed therapeutic effect and inhibition of expansion of leading links of an atherogenesis.