Open AccessBenzobarbital and fluorbenzobarbital - hepatic monooxygenase system phenobarbital-like inducers
Author(s) -
Татьяна Петровна Новожеева,
Marina Smagina,
Н. А. Черевко,
С. Н. Фатеева
Publication year - 2011
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2011-5-78-81
Subject(s) - phenobarbital , monooxygenase , inducer , metabolite , hydroxylation , cytochrome , chemistry , enzyme inducer , aniline , isozyme , cytochrome p450 , biochemistry , enzyme , pharmacology , biology , organic chemistry , gene
Benzobarbital and fluorbenzobarbital as monooxygenase system inductors increase the hepatic cytochrome P-450 level and the content of its isoenzymes 2B6, 2C9, 2Å1, accelerate aminopyrine, 7-ethoxyresorufine, 7-pentoxyresorufine, aniline and androstendione oxidation. Activity of benzobarbital and fluorbenzobarbital as inductors is to a large degree due to the action of their major metabolite — phenobarbital. Benzobarbital and fluorbenzobarbital unlike phenobarbital induce isoenzyme 3A4, responsible for androstendione 16b-OH-hydroxylation. PCN-type induction activity posses also native molecules of benzobarbital and fluorbenzobarbital.