Open AccessThe etno-population features of IL-1 β gene polimorfism distribution at Helicobacter pylori-associated gastroduodenal pathology
Author(s) -
Е. С. Агеева,
О. В. Штыгашева,
Н. В. Рязанцева,
V. N. Kharkov,
Vadim Stepanov
Publication year - 2011
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2011-3-14-18
Subject(s) - helicobacter pylori , gastritis , genotype , interleukin 1 receptor antagonist , gene polymorphism , biology , interleukin , chronic gastritis , population , gastroenterology , gene , pathology , medicine , immunology , receptor antagonist , receptor , antagonist , genetics , cytokine , environmental health
The aim of this study was to reveal the features of association polymorphisms of interleukin-1 IL-1 and the antagonist of receptor for interleukin-1 IL-1Ra gene polymorphism in Mongoloids and Caucasoid from Khakassia with HP-associated gastroduodenal pathology (chronic gastritis and gastric ulcer). It was revealed that among Khakasses the most widespread genotypes among Khakasses are СС IL-1β and R4R4 IL-1Ra. The association of СС +3953 and R2R3 genotypes with GU risk in Caucasoids was found.